Binding molecules binding PD-L1 and LAG-3

Binding molecules binding PD-L1 and LAG-3

The present disclosure relates to antibody molecules which bind to programmed death-ligand 1 (PD-L1) and lymphocyte-activation gene 3 (LAG-3). The antibody molecules preferably comprise a CDR-based antigen binding site for PD-L1, and a LAG-3 antigen binding site which may be located in two or more s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wollerton Van Horck, Francisca, Kraman, Matthew, Hebeis, Barbara, Tuna, Mihriban, Gaspar, Miguel, Faroudi, Mustapha, Fosh, Natalie, Kmiecik, Katarzyna, Everett, Katy Louise, Campbell, Jamie, Sandy, Nikole
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates to antibody molecules which bind to programmed death-ligand 1 (PD-L1) and lymphocyte-activation gene 3 (LAG-3). The antibody molecules preferably comprise a CDR-based antigen binding site for PD-L1, and a LAG-3 antigen binding site which may be located in two or more structural loops of a CH3 domain of the antibody molecule. The antibody molecules of the disclosure find application, for example, in cancer therapy.