Methods for the use of CD32B x CD79B-binding molecules in the treatment of inflammatory diseases and disorders

Methods for the use of CD32B x CD79B-binding molecules in the treatment of inflammatory diseases and disorders

The present invention is directed to methods for using bispecific binding molecules that possess a binding site specific for an epitope of CD32B and a binding site specific for an epitope of CD79B, and are thus capable of simultaneous binding to CD32B and CD79B. The invention particularly concerns s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Wei, Wigginton, Jon Marc, Pandya, Naimish Bharat, Bonvini, Ezio, Moore, Paul A
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention is directed to methods for using bispecific binding molecules that possess a binding site specific for an epitope of CD32B and a binding site specific for an epitope of CD79B, and are thus capable of simultaneous binding to CD32B and CD79B. The invention particularly concerns such molecules that are bispecific antibodies or bispecific diabodies (and especially such diabodies that additionally comprise an Fc Domain). The invention is directed to the use of such molecules, and to the use of pharmaceutical compositions that contain such molecules in the treatment of inflammatory diseases or conditions.