Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof

Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof

The present invention provides variant activin JIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TAM, Lei-Ting Tony, SUN, Jeonghoon, LU, John, HAN, Huiquan, KWAK, Keith Soo-Nyung, ZHOU, Xiaolan
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides variant activin JIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.