COMPOSITIONS AND METHODS DIRECTED TO TREATING LIVER FIBROSIS

Abstract The invention relates to double-stranded ribonucleic acid (dsRNA) for inhibiting expression of collagen 1A1 (COL1A1), transforming growth factor beta 1 (TFGP) and/or SMAD homolog 2 and 3 (SMAD2/3) and methods of treating chronic liver disease characterised by liver fibrosis thereof.

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Bibliographische Detailangaben
Hauptverfasser:	Sehgal, Alfica, Bettencourt, Brian, Novobrantseva, Tatiana, Hinkle, Greg, Kotelianski, Victor
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Abstract The invention relates to double-stranded ribonucleic acid (dsRNA) for inhibiting expression of collagen 1A1 (COL1A1), transforming growth factor beta 1 (TFGP) and/or SMAD homolog 2 and 3 (SMAD2/3) and methods of treating chronic liver disease characterised by liver fibrosis thereof.