Immuno-based botulinum toxin serotype A activity assays

IMMUNO-BASED BOTULINUM TOXIN SEROTYPE A ACTIVITY ASSAYS Abstract The present specification discloses SNAP-25 compositions, methods of making a-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage...

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Bibliographische Detailangaben
Hauptverfasser:	Wang, Joanne, Aoki, Kei Roger, Fernandez-Salas, Ester, Wong, Lina S, Garay, Patton E, Hodges, Dianne D
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
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Zusammenfassung:	IMMUNO-BASED BOTULINUM TOXIN SEROTYPE A ACTIVITY ASSAYS Abstract The present specification discloses SNAP-25 compositions, methods of making a-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, a-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P, residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing a-BoNT/A antibodies.