Processes for making compounds useful as inhibitors of ATR kinase

Abstract [002821 The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. [002831 The compounds of this invention have formula I or II: NH 0 -N NH2 04 H -R4 R N- Rla RC R4 R lb wherein the variables are as defined herein.