Antibodies with modified isoelectric points

Antibodies with modified isoelectric points

Il:\sxdInterwoven\NRPortbl\DCC\SXD\15178813_l.docx-12/07/2017 The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo.

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Bibliographische Detailangaben
Hauptverfasser: Bernett, Matthew J, Dahiyat, Bassil I, Lazar, Gregory A
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:Il:\sxdInterwoven\NRPortbl\DCC\SXD\15178813_l.docx-12/07/2017 The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo.