Use of anatabine to treat inflammation and methods of synthesizing anatabine

Use of anatabine to treat inflammation and methods of synthesizing anatabine

H:\xd\Interwoven\NRPortbl\DCC\SXD\I33562121.docx-8/03/2017 Pharmaceutical compositions comprising an isolated form of anatabine or a salt thereof can be used to treat disorders comprising an inflammatory component, including chronic, low level inflammation. In another aspect, methods for the synthet...

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Hauptverfasser: Raju, Muppala Sarveswara, Puthiaparampil, Tom Thomas, Williams, Jonnie R, David, Thomas Kanathkunn
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:H:\xd\Interwoven\NRPortbl\DCC\SXD\I33562121.docx-8/03/2017 Pharmaceutical compositions comprising an isolated form of anatabine or a salt thereof can be used to treat disorders comprising an inflammatory component, including chronic, low level inflammation. In another aspect, methods for the synthetic preparation of anatabine involve reacting benzophenoneimine with 3-aminomethyl pyridine to form benzylhydrylidene pyridin-3-yl-methyl-amine. The benzylhydrylidene-pyridin-3-yl-methyl-amine is treated with a non-nucleophilic base and a dielectrophile, such as cis- 1,4-dichloro-2-butene, followed by acidification, then basification, to provide anatabine. 100 ______ E_ RACEMIO MIXTURE )S (S-(-)-ANATABINE Lu co40 0 10 100 200 400 600 800 1000 DOSE (pg/mL)