Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated disease and conditions

Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated disease and conditions

DIFLUOROLACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASE AND CONDITIONS Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), where Li, L2, L4, R4, R5, R6 and s are as defined in the speci...

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Hauptverfasser: KRAMER, James Bernard, GERMAIN, Bradlee David, UZIEBLO, Adam, MAXEY, Kirk M, KOMILOV, Andriy, CISKE, Fred Lawrence, COLOMBO, Joseph Michael, ENDRES, Gregory William, BARRETT, Stephen Douglas
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:DIFLUOROLACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASE AND CONDITIONS Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), where Li, L2, L4, R4, R5, R6 and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.