Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity

The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the...

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Bibliographische Detailangaben
Hauptverfasser:	Peach, Joanne, Noble, Martin Edward Mäntylä, Mitchell, Dale Robert, Cano, Celine Florence, Miller, Duncan Charles, Osborne, James Daniel, Whittaker, Benjamin Paul, Chessari, Gianni, Cons, Benjamin David, Holvey, Rhian Sara, Cully, Sarah, Tamanini, Emiliano, Lewis, Arwel, Buck, Ildiko Maria, Griffin, Roger John, Watson, David Wyn, Hirst, Kim Louise, Rees, David Charles, St. Denis, Jeffrey David, Golding, Bernard Thomas, Hardcastle, Ian Robert, Johnson, Christopher Norbert, Howard, Steven
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.