Vaccine compositions having improved stability and immunogenicity

Vaccine compositions having improved stability and immunogenicity

Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Shane, Erica, Massare, Michael, Boddapati, Sarathi, Glenn, Gregory, Smith, Gale, Liu, Ye, Tian, Jing-Hui, Oliver, Cynthia
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.