Tetrahydrooxepinopyridine compound

[Problem] To provide a compound which has a positive allosteric modulating effect (PAM effect) for an α7 nicotinic acetylcholine receptor (α7 nACh receptor). [Solution] The inventors have achieved the present invention by making studies on PAM effects for an α7 nACh receptor and confirming that a te...

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Bibliographische Detailangaben
Hauptverfasser:	Koganemaru, Yohei, Miyamoto, Satoshi, Kamikawa, Akio, Aoki, Satoshi, Koizumi, Yuka, Yonezawa, Koichi, Kawakami, Shimpei, Kakimoto, Shuichirou, Sato, Ryo, Tamaki, Keisuke, Yamada, Hiroshi, Nagashima, Shinya, Kunikawa, Shigeki, Ogiyama, Takashi, Shishikura, Junichi
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	[Problem] To provide a compound which has a positive allosteric modulating effect (PAM effect) for an α7 nicotinic acetylcholine receptor (α7 nACh receptor). [Solution] The inventors have achieved the present invention by making studies on PAM effects for an α7 nACh receptor and confirming that a tetrahydrooxepinopyridine compound has a PAM effect for an α7 nACh receptor. A tetrahydrooxepinopyridine compound according to the present invention has a PAM effect for an α7 nACh receptor, and is promising as a prophylactic or therapeutic agent for dementia, cognitive impairment, schizophrenia, Alzheimer's disease, CIAS, negative symptoms of schizophrenia, inflammatory diseases or pain.