PROCESS FOR THE PREPARATION OF A SULFATED DERIVATIVE OF 3,5-DIIODO-O-[3-IODOPHENYL]-L-TYROSINE

PROCESS FOR THE PREPARATION OF A SULFATED DERIVATIVE OF 3,5-DIIODO-O-[3-IODOPHENYL]-L-TYROSINE

The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L tyrosine (T3S) by starting from the corresponding phenolic compound, in 5 the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Boi, Valeria, Cavalieri, Livio, Galimberti, Laura, Rivolta, Giovanni, Vella, Fulvia, Anelli, Pier Lucio, Argese, Maria, Lattuada, Luciano, Gazzetto, Sonia, Maisano, Federico
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Beschreibung
Zusammenfassung:The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L tyrosine (T3S) by starting from the corresponding phenolic compound, in 5 the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of 10 such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.