Crystal of salt of novel 3-azabicyclo[3.1.0]hexane derivative and pharmaceutical use thereof

The objective of the present invention is to provide: a crystal having high purity and excellent properties (such as stability and solubility) of a highly safe compound with few side effects, said compound having μ-opioid receptor antagonist activity; and a method for producing this crystal. A cryst...

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Bibliographische Detailangaben
Hauptverfasser:	Takama, Akira, Kuno, Yuka, Setoguchi, Hiroyuki, Tsuzaki, Yasunori, Akaza, Hiroto, Iwamura, Ryo, Yamamoto, Yasuhito
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The objective of the present invention is to provide: a crystal having high purity and excellent properties (such as stability and solubility) of a highly safe compound with few side effects, said compound having μ-opioid receptor antagonist activity; and a method for producing this crystal. A crystal of a salt or hydrate thereof, said salt being composed of a compound represented by formula (I) and an acid selected from the group consisting of hydrochloric acid, hydrobromic acid and oxalic acid. (In the formula, R