Methods and composition for determining pH

Described herein are nucleic acid molecules and complexes useful as i-switch pH reporters that have increased sensitivities as a pH reporter and have alternate pH reporting capacity ranges. Aspects of the disclosure relate to a method for determining pH comprising providing a nucleic acid complex co...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Halder, Saheli, Krishnan, Yamuna
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Described herein are nucleic acid molecules and complexes useful as i-switch pH reporters that have increased sensitivities as a pH reporter and have alternate pH reporting capacity ranges. Aspects of the disclosure relate to a method for determining pH comprising providing a nucleic acid complex comprising: a first single-stranded nucleic acid molecule comprising the sequence C