Tricyclic sulfones as ROR¿ modulators

There are described RORϒ modulators of the formula (I), and formula (II) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and c...

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Bibliographische Detailangaben
Hauptverfasser:	Dhar, T.G. Murali, Cornelius, Lyndon A.M, Beaudoin Bertrand, Myra, Duan, Jingwu, Shi, Qing, Srivastava, Anurag S, Liu, Qingjie, Marcoux, David, Weigelt, Carolyn A, Cherney, Robert J, Batt, Douglas G
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	There are described RORϒ modulators of the formula (I), and formula (II) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORϒ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORϒ activity, for example, autoimmune and/or inflammatory disorders.