Cationic steroidal antimicrobial salts

Disclosed herein are acid addition salts of cationic steroidal antimicrobials ("CSAs" or "ceragenins") and methods of making the same. Particularly advantageous salt forms are identified, such as 1,5-naphthalenedisulfonic acid addition salts and sulfate addition salts. The acid a...

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Bibliographische Detailangaben
Hauptverfasser: Miller, Ross Allen, Varia, Kunal Arvind, Chitre, Saurabh Shashikant, Randall, Jared Lynn, Jacks, Thomas Elliot, Savage, Paul B, Reece, Hayley Ann
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed herein are acid addition salts of cationic steroidal antimicrobials ("CSAs" or "ceragenins") and methods of making the same. Particularly advantageous salt forms are identified, such as 1,5-naphthalenedisulfonic acid addition salts and sulfate addition salts. The acid addition salts may be formulated for treating subjects with ailments responsive to CSAs, including but not limited to treating bacterial infections. Embodiments include formulations and methods of administering acid addition salts of CSAs.