1' -substituted carba-nucleoside analogs for antiviral treatment

Provided are pyrrolo[ 1,2-fl [1,2,4]triazinyl, imidazo[ 1,5-fl [1,2,4]triazinyl, imidazo[ 1,2 f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the I 'position of the nucleoside sugar is substituted. The 5 compounds,...

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Bibliographische Detailangaben
Hauptverfasser:	Saunders, Oliver L, Parrish, Jay, Butler, Thomas, Zhang, Lijun, Cho, Aesop, Kim, Choung U
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	Provided are pyrrolo[ 1,2-fl [1,2,4]triazinyl, imidazo[ 1,5-fl [1,2,4]triazinyl, imidazo[ 1,2 f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the I 'position of the nucleoside sugar is substituted. The 5 compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections. Formula (I), each X or X2 is independently C-R 10or N. Fonnula I