Bispecific antibody constructs for CDH3 and CD3

Bispecific antibody constructs for CDH3 and CD3

The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encodi...

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Bibliographische Detailangaben
Hauptverfasser: Nahrwold, Lisa, Raum, Tobias, Rau, Doris, Zierz, Ruprecht, Kufer, Peter, Hoffmann, Patrick, Blümel, Claudia, Frisk, Ann-Lena, Lutterbüse, Ralf, Dahlhoff, Christoph, Weiss, Bertram, Anlahr, Jonas
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transiected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.