Process for Making Modulators of Cystic Fibrosis Transmembrane Conductance Regulator

Process for Making Modulators of Cystic Fibrosis Transmembrane Conductance Regulator

The invention provides a process for the preparation of a compound of Formula 1, N H (Rx-X H R2 Formula 1 comprising coupling a carboxylic acid of Formula 2 (Rx-X OH Formula 2 with an aniline of Formula 3 Formula 3 in the presence of a coupling agent.

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Bibliographische Detailangaben
Hauptverfasser: Ryan, Michael P, Trudeau, Martin, Grootenhuis, Peter D.J, Zlokarnik, Gregor, Krueger, Brian R, Looker, Adam R, Van Goor, Fredrick F, Neubert-Langille, Bobbianna J, Guerette, Dahrika Milfred Lao Yap, DeMattei, John, Roeper, Stefanie, Botfield, Martyn C
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention provides a process for the preparation of a compound of Formula 1, N H (Rx-X H R2 Formula 1 comprising coupling a carboxylic acid of Formula 2 (Rx-X OH Formula 2 with an aniline of Formula 3 Formula 3 in the presence of a coupling agent.