Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith

Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith

SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH [0001] Provided herein are Diaminopyrimidine Compounds having the following structures: -- N HN N NH HN N NH 1 o2 F or Rs (I) (IB) wherein R , R , R , and R4 are as defined he...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Delgado, Mercedes, Bennett, Brydon, Ann Lebrun, Laurie, Sloss, Marianne, Norris, Stephen, Paisner, David A, Elsner, Jan, McCarrick, Meg, Satoh, Yoshitaka, Moghaddam, Mehran F, Nagy, Mark A, Romanow, William, Yoon, Won Hyung, Tikhe, Jayashree, Erdman, Paul, Hilgraf, Robert
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH [0001] Provided herein are Diaminopyrimidine Compounds having the following structures: -- N HN N NH HN N NH 1 o2 F or Rs (I) (IB) wherein R , R , R , and R4 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidine Compound, and methods for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.