Microprojection array applicator and method

The present invention relates to applicators for administering microprojection arrays to skin and methods of administering microprojection arrays. One embodiment of the present invention is a device for applying a microprojection array to a skin surface comprising: a) a housing having an upper and lower portion and having an internal face and an external face wherein the external face has a flexible section that when collapsed actuates the device; b) a patch guide having a proximal and distal end wherein the proximal end interfaces with the internal face of the housing such that when the flexible section of the external face of the housing is collapsed the patch guide is forced downward; c) a cantilevered ring having an opening through which the patch guide passes and wherein the cantilevered ring is activated by the patch guide; d) a microprojection array that is contacted by the cantilevered ring when the ring is activated; e) a skin contact membrane; and f) a skin contact applicator base that attaches to the housing. A further embodiment of the present invention also includes two or more cantilevered rings having a first and a last ring, wherein the cantilevered rings are stacked such that when the device is actuated the first ring is fired such that each successive ring is contacted by the preceding ring.