Adsorption of immunopotentiators to insoluble metal salts

Adsorption of immunopotentiators to insoluble metal salts

ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory 5 effect. Immunopotentiators are modified to intr...

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Hauptverfasser: SINGH, MANMOHAN, LI, YONGKAI, CORTEZ, ALEX, SKIBINSKI, DAVID A.G, YUE, KATHY, WU, TOM, ZHENG, XIAOYUE, PAN, JLANFENG, ZOU, YEFEN, HOFFMAN, TIMOTHY
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory 5 effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.