Optimizing operating binding capacity for a multiple column chromatography process

The invention relates to multiple column chromatography (MCC). MCC is complicated and there is a need for improved MCC process development, The invention provides methods for optimizing the operating binding capacity for a multiple column chromatography (MCC) process. In particular, the invention pr...

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Hauptverfasser:	Schofield, Mark J, Rogler, Karl K, Gjoka, Xhorxhi
Format:	Patent
Sprache:	eng
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS SEPARATION TESTING TRANSPORTING
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Beschreibung
Zusammenfassung:	The invention relates to multiple column chromatography (MCC). MCC is complicated and there is a need for improved MCC process development, The invention provides methods for optimizing the operating binding capacity for a multiple column chromatography (MCC) process. In particular, the invention provides methods for determining an optimum operating binding capacity for the MCC process. Product Feed Column A Coimn B (X) amount bound to coumn A ( Y amount bound to column B 2 -Column A Inlet concentration Column A Outlet concentration w Column B Outlet concentration C0,4 0 2C) 40 60 0 10 Time. (min) Start of product breakthrough at column B outlet RTt Coclmtm A VRT= f R=2a L Fv RT= C C umr\BV -Gv 4IU