Novel compounds as opioid receptor modulators

Abstract The present invention is directed to novel opioid receptor modulators of Formula: (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors. Figure 1 Figure 1 Recording distensions @ 4 min intervals 2 minutes 20 2f dissension pressures- 40 4D 60 80 40 60 90 40 60 80 (mnmH9 intrmaoloic EMGrecordings b"llc"pnsitard (distension time- 20 sea) Zymosan treatment 0 hours 4 5 6 t t t t 1.3 ml zymsan A record treat wit record (25 m/dl in 30% EtOH) oiound tuiBCialcat aC iminstratisn