MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS
[0469] Compounds of Formula I and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious...
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| creator | Yang, Hong-Woon Zhao, Qian Andrews, Steven Wade Jiang, Yutong Seo, Jeongbeob Condroski, Kevin Ronald Haas, Julia Kolakowski, Gabrielle R |
| description | [0469] Compounds of Formula I and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases. |
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Haas, Julia ; Kolakowski, Gabrielle R</creatorcontrib><description>[0469] Compounds of Formula I and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201112&DB=EPODOC&CC=AU&NR=2016203348C1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201112&DB=EPODOC&CC=AU&NR=2016203348C1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Yang, Hong-Woon</creatorcontrib><creatorcontrib>Zhao, Qian</creatorcontrib><creatorcontrib>Andrews, Steven Wade</creatorcontrib><creatorcontrib>Jiang, Yutong</creatorcontrib><creatorcontrib>Seo, Jeongbeob</creatorcontrib><creatorcontrib>Condroski, Kevin Ronald</creatorcontrib><creatorcontrib>Haas, Julia</creatorcontrib><creatorcontrib>Kolakowski, Gabrielle R</creatorcontrib><title>MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS</title><description>[0469] Compounds of Formula I and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNDzdXQO8neOdPbxdFZw9vcN8A_1cwlWcAxWCAnyVvD29HMMdlXw9PPwdPIM8Q8K5mFgTUvMKU7lhdLcDCpuriHOHrqpBfnxqcUFicmpeakl8Y6hRgaGZkYGxsYmFs7OhsZEKgMAzY8nJw</recordid><startdate>20201112</startdate><enddate>20201112</enddate><creator>Yang, Hong-Woon</creator><creator>Zhao, Qian</creator><creator>Andrews, Steven Wade</creator><creator>Jiang, Yutong</creator><creator>Seo, Jeongbeob</creator><creator>Condroski, Kevin Ronald</creator><creator>Haas, Julia</creator><creator>Kolakowski, Gabrielle R</creator><scope>EVB</scope></search><sort><creationdate>20201112</creationdate><title>MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS</title><author>Yang, Hong-Woon ; 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS |
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