MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS

MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS

[0469] Compounds of Formula I and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yang, Hong-Woon, Zhao, Qian, Andrews, Steven Wade, Jiang, Yutong, Seo, Jeongbeob, Condroski, Kevin Ronald, Haas, Julia, Kolakowski, Gabrielle R
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:[0469] Compounds of Formula I and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.