Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof

Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof

Abstract Disclosed is a composition comprising recombinant iduronate-2-sulfatase (IDS). The glycosylation pattern and formylglycine content of the IDS composition are different from those of Elaprase and have superior pharmaceutical efficacy and are safer than the conventional agent and thus can be...

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Bibliographische Detailangaben
Hauptverfasser: SEO, Jinwook, CHOI, Yong Woon, CHUNG, Yo Kyung, KIM, Yong-Chul, PAIK, Sang Hoon, PARK, Yoo Chang, JIN, Thong-Gyu, SON, Jong Mun
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Abstract Disclosed is a composition comprising recombinant iduronate-2-sulfatase (IDS). The glycosylation pattern and formylglycine content of the IDS composition are different from those of Elaprase and have superior pharmaceutical efficacy and are safer than the conventional agent and thus can be effectively used for the therapy of Hunter syndrome.