Phenyl amino pyrimidine compounds and uses thereof

The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are 5 selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Burns, Christopher John, Nguyen, Thao Lien Thi, Wilks, Andrew Frederick, Zeng, Jun, Donohue, Andrew Craig, Feutrill, John Thomas
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are 5 selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.