Fused pentacyclic imidazole derivatives

A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nocice...

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Bibliographische Detailangaben
Hauptverfasser:	Quincey, Joanna Rachel, Deligny, Michael, Shaw, Michael Alan, Keyaerts, Jean, Jadot, Sophie, Mac Coss, Malcolm, Zhu, Zhaoning, Brookings, Daniel Christopher, Hutchings, Martin Clive, Foricher, Yann, Filoche-Romme, Bruno, Calmiano, Mark Daniel, Schio, Laurent, Swinnen, Dominique Louis Leon, Heer, Jag Paul, Selby, Matthew Duncan, Xuan, Mengyang, Evrard, Yves, De Haro Garcia, Teresa, Johnson, James Andrew
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[l,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.