Azetidines as MEK inhibitors for the treatment of proliferative diseases

Azetidines as MEK inhibitors for the treatment of proliferative diseases

Abstract Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as...

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Bibliographische Detailangaben
Hauptverfasser: KOLTUN, ELENA, BUSSENIUS, JOERG, KENNEDY, ABIGAIL R, MANALO, JEAN-CLAIRE LIMUN, PETO, CSABA J, DUBENKO, LARISA, CURTIS, JEFFRY KIMO, AAY, NAING, BLAZEY, CHARLES M, COSTANZO, SIMONA, JOSHI, ANAGHA ABHIJIT, BOWLES, OWEN JOSEPH, KIM, ANGIE INYOUNG, RICE, KENNETH D, ANAND, NEEL KUMAR, TSANG, TSZE H, DEFINA, STEVEN CHARLES
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Abstract Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.