Reconstitution of pharmaceuticals for injection

A device is disclosed for reconstitution and delivery of an injectable pharmaceutical. A diluent is provided in a pressurized reservoir, while separately a syringe with a needle contains a pharmaceutical such as a lyophilized drug. When the pressurized reservoir is coupled to the interior of the syringe, such as by piercing the pressurized reservoir with the needle, the pressurized reservoir forces the diluent into the syringe where the diluent can mix with and reconstitute the pharmaceutical. A variety of techniques are disclosed for pressurizing the reservoir and fluidly coupling the reservoir with the syringe. The techniques disclosed herein may, for example, be adapted for use with a conventional syringe and needle.