PEPTIDE-BASED IN VIVO SIRNA DELIVERY SYSTEM
Abstract The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepaiocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin dehvery peptides. Dehvery peptides provide membrane penetration faction f...
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| creator | Lewis, David L Hadwiger, Philipp Carlson, Jeffrey C Roehl, Ingo Benson, Jonathan D Ott, Guenther Mohr, Peter Rozema, David B Kitas, Eric Mueller, Hans Martin Hoffman, Torsten Wakefield, Darren H Jahn-Hofmann, Kerstin Wolff, Jon A Blokhin, Andrei V |
| description | Abstract The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepaiocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin dehvery peptides. Dehvery peptides provide membrane penetration faction for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides. |
| format | Patent |
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Targeted RNAi polynucleotides are administered together with co-targeted melittin dehvery peptides. Dehvery peptides provide membrane penetration faction for movement of the RNAi polynucleotides from outside the cell to inside the cell. 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Targeted RNAi polynucleotides are administered together with co-targeted melittin dehvery peptides. Dehvery peptides provide membrane penetration faction for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.</abstract><oa>free_for_read</oa></addata></record> |
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| title | PEPTIDE-BASED IN VIVO SIRNA DELIVERY SYSTEM |
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