PEPTIDE-BASED IN VIVO SIRNA DELIVERY SYSTEM

Abstract The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepaiocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin dehvery peptides. Dehvery peptides provide membrane penetration faction f...

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Bibliographische Detailangaben
Hauptverfasser:	Lewis, David L, Hadwiger, Philipp, Carlson, Jeffrey C, Roehl, Ingo, Benson, Jonathan D, Ott, Guenther, Mohr, Peter, Rozema, David B, Kitas, Eric, Mueller, Hans Martin, Hoffman, Torsten, Wakefield, Darren H, Jahn-Hofmann, Kerstin, Wolff, Jon A, Blokhin, Andrei V
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Abstract The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepaiocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin dehvery peptides. Dehvery peptides provide membrane penetration faction for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.