DNA polymerase mutants having enhanced template discrimination activity

DNA polymerase mutants having enhanced template discrimination activity

This invention relates to mutant DNA polymerases having an enhanced template discrimination activity compared with the corresponding unmodified DNA polymerase counterparts, wherein the amino acid sequence of the mutant DNA polymerase includes at least one substitution at residue positions structural...

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Bibliographische Detailangaben
Hauptverfasser: RUPP, SUSAN M, WALDER, JOSEPH A, ROSE, SCOTT D, DOBOSY, JOSEPH R, OWCZARZY, RICHARD, BEHLKE, MARK AARON
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
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MICROBIOLOGY
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Beschreibung
Zusammenfassung:This invention relates to mutant DNA polymerases having an enhanced template discrimination activity compared with the corresponding unmodified DNA polymerase counterparts, wherein the amino acid sequence of the mutant DNA polymerase includes at least one substitution at residue positions structurally and functionally homologous or orthologous positions 783 or 784 of an unmodified Taq DNA polymerase.