Human antibodies that bind human IL-12 and methods for producing

HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING THE SAME 5 Abstract Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in...

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Hauptverfasser:	MYLES, ANGELA, SALFELD, JOCHEN G, CARMEN, SARA, ELVIN, JOHN GAWAIN, WARNE, NICHOLAS W, BANERJEE, SUBHASHIS, SMITH, STEPHEN, DUNCAN, ALEXANDER ROBERT, FRIEDRICH, STUART, TRACEY, DANIEL EDWARD, DU FOU, SARAH LEILA, LABKOVSKY, BORIS, VENTURINI, AMY, DERBYSHIRE, ELAINE J, KAYMAKCALAN, ZEHRA, HOLTET, THOR LAS, PASKIND, MICHAEL, WIDOM, ANGELA, WHITE, MICHAEL, VELDMAN, GEERTRUIDA M, ROGUSKA, MICHAEL, SAKORAFAS, PAUL
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING THE SAME 5 Abstract Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo- An antibody of the 10 invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL- 12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the 15 recombinant human antibodies, are also encompassed by the invention.