Method for preparing particles comprising metal oxide coating and particles with metal oxide coating

Particles comprising a particulate matter coated by a metal oxide layer wherein: (i) said metal oxide layer has a width of 0.1 -10 micron; and (ii) said particles are characterized in that when tested in a Dissolution Tester using Paddle Method in a medium, typically an organic-based solvent such as...

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Bibliographische Detailangaben
Hauptverfasser: BAR-SIMANTOV, HAIM, SOMMER, WILLIAM T, BILMAN, NISSIM, TOLEDANO, OFER, ABU-REZIQ, RAED, SHAPIRO, LEORA, SRIADIBHATLA, SRIKAN
Format: Patent
Sprache:eng
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Zusammenfassung:Particles comprising a particulate matter coated by a metal oxide layer wherein: (i) said metal oxide layer has a width of 0.1 -10 micron; and (ii) said particles are characterized in that when tested in a Dissolution Tester using Paddle Method in a medium, typically an organic-based solvent such as acetonitrile, iso propyl miristate, ethanol or methanol, in which said particulate matter is soluble, and a dissolution volume in which the concentration of the particulate matter is -lower than the solubility of the particulate matter, the time for releasing 50% w/w of the particulate matter from said particles is at least two-fold higher compared to the dissolution of the free form of the particulate matter having substantially the same particle size diameter as the particulate matter in said particles.