Aminopyrimidines as Syk inhibitors

AMINOPYRIMIDINES AS SYK INHIBITORS Abstract The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

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Bibliographische Detailangaben
Hauptverfasser:	KATTAR, SOLOMON, CHILDERS, KALEEN KONRAD, ANDRESEN, BRIAN M, KNOWLES, SANDRA LEE, GUAY, DANIEL, ROBICHAUD, JOEL S, O'BOYLE, BRENDAN M, FOURNIER, JEAN-FRANCOIS, SCHELL, ADAM J, ALTMAN, MICHAEL D, MACHACEK, MICHELLE R, ARRINGTON, KENNETH L, FRANCESCO, MARIA EMILIA DI, GAUTHIER, JACQUES YVES, ROMEO, ERIC, OTTE, RYAN D, LIM, JONGWON, COTE, BERNARD, BURCH, JASON, REUTERSHAN, MICHAEL H, DUPONT-GAUDET, KRISTINA, GUERIN, DAVID JOSEPH, NORTHRUP, ALAN B, SIU, TONY, WOO, HYUN CHONG, MADDESS, MATTHEW L, ELLIS, JOHN MICHAEL, BHAT, SATHESH, TROTTER, B. WESLEY, SPENCER, KERRIE B, PETROCCHI, ALESSIA, FISCHER, CHRISTIAN, HAIDLE, ANDREW M, ZHOU, HUA, DONOFRIO, ANTHONY, TAOKA, BRANDON M, GRIMM, JONATHAN, LI, CHAOMIN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	AMINOPYRIMIDINES AS SYK INHIBITORS Abstract The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.