Oral form, comprising immediate-release coated particles of at least one active compound that are grinding-resistant

The present invention relates to an immediate-release oral form of at least one active compound, comprising coated particles formed of a non-monocrystalline core containing said active compound and coated with at least one coating layer, said coating layer comprising (A) at least 15% by weight of a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DAVIAUD-VENET, ANNE-SOPHIE, CASTAN, CATHERINE
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to an immediate-release oral form of at least one active compound, comprising coated particles formed of a non-monocrystalline core containing said active compound and coated with at least one coating layer, said coating layer comprising (A) at least 15% by weight of a water-insoluble polymer and (B) at least 40% by weight of a polymer soluble in a hydrochloric acid solution 0, 1N, the weighted ratio polymer B/polymer A being between 85/15 and 50/50, said coating layer representing at least 30% by weight of the total weight of said coated particles. It also relates to the use of such particles for preparing an immediate-release oral form of said active compound.