Piperazinotrizole compound, preparation method therefor, and use thereof in drug preparation

Provided is a piperazinotrizole compound represented by general formula I or an isomer, a pharmaceutically acceptable salt, ester, prodrug or hydrate thereof. Also provided are a method for preparing the compound, a drug composition containing the compound, and a use thereof as a high-selectivity po...

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Bibliographische Detailangaben
Hauptverfasser:	MIAO, ZEHONG, ZHANG, AO, CHEN, CHUANHUIZI, HUAN, XIAJUAN, SONG, ZILAN, DING, JIAN, CHEN, YI, YE, NA
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided is a piperazinotrizole compound represented by general formula I or an isomer, a pharmaceutically acceptable salt, ester, prodrug or hydrate thereof. Also provided are a method for preparing the compound, a drug composition containing the compound, and a use thereof as a high-selectivity poly(ADP-ribose) polymerase-1 (PARP1) inhibitor in the preparation of drugs for the prevention and/or treatment of PARP-related diseases.