Heterobicyclic compounds and their use as phosphodiesterase inhibitors

Heterobicyclic compounds of Formula (I): (I); or a pharmaceutically-acceptable salt, tautomer, or stereoisomer thereof, as defined in the specification, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases tr...

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Hauptverfasser:	ZHONG, WENGE, RUMFELT, SHANNON, CHEN, NING, LIU, QINGYIAN, ALLEN, JENNIFER R, QIAN, WENYUAN, RZASA, ROBERT M, ANDREWS, KRISTIN L, NGUYEN, THOMAS T, YUAN, CHESTER CHENGUANG, CHEN, JIAN J, BROWN, JAMES, HARRINGTON, ESSA HU, AMEGADZIE, ALBERT, PICKRELL, ALEXANDER J
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Heterobicyclic compounds of Formula (I): (I); or a pharmaceutically-acceptable salt, tautomer, or stereoisomer thereof, as defined in the specification, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, Huntington's Disease, and the like.