Stabilized pharmaceutical formulations of a potent HCV inhibitor

Described are various methods for stabilizing pharmaceutical formulations of a specific Hepatitis C Viral (HCV) inhibitor against the formation of a particular genotoxic degradation product. Such methods include temperature control, moisture control, excipient control, capsule shell control, basific...

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Bibliographische Detailangaben
Hauptverfasser:	BRAUN, MATHIAS, GUMP, EDWIN LOUIS, QIU, FENGHE, MAJESKA, JENNESS B, VILLAGRA, MARIA FERNANDA, BUSACCA, CARL ALAN, PENNINO, SCOTT, CHEN, FENG-JING
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	Described are various methods for stabilizing pharmaceutical formulations of a specific Hepatitis C Viral (HCV) inhibitor against the formation of a particular genotoxic degradation product. Such methods include temperature control, moisture control, excipient control, capsule shell control, basification and a reconstitution approach.