Enhanced cytotoxicity of anti-CD74 and anti-HLA-DR antibodies with interferon-gamma

Disclosed herein are methods and compositions comprising interferon-y (IFN-y) and anti CD74 or anti-HLA-DR antibodies. In preferred embodiments, the IFN-y increases the expression of CD74 and/or HLA-DR in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD...

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Bibliographische Detailangaben
Hauptverfasser:	STEIN, RHONA, BURTON, JACK D, GOLDENBERG, DAVID M
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	Disclosed herein are methods and compositions comprising interferon-y (IFN-y) and anti CD74 or anti-HLA-DR antibodies. In preferred embodiments, the IFN-y increases the expression of CD74 and/or HLA-DR in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 or anti-HLA-DR antibodies. The compositions and methods are of use to treat diseases involving CD74' and/or HLA-DR' cells, such as cancer cells, autoimmune disease cells or immune dysfunction disease cells.