METHYLPHENIDATE DERIVATIVES AND USES OF THEM

The present invention provides methods of using compounds of formula I: (R')nS and salts and prodrugs thereof, wherein n, R1 and R2 are defined herein. The invention also provides certain novel compounds of formula I and pharmaceutical compositions comprising them. ' / t 2 ug/mi PHA nm 0 0.1 0.2 0.3 0. 0.5 -4 Nil - Dex Cpd Il 50 ug/ml MP 50 ug/mI PHA + water PHA + Dex PHA + Cpd II 50 ug/ml PHA + Cpd 1115 ug/ml PHA + Cpd l15 ug/ml PHA + MP 50 ug/ml PHA + MP 15 ug/ml PHA + MP 5 ug/ml Figure IA 5 ug/ml PHA OD 530 nm 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 Nil PHA + water PHA + Dex PHA + Cpd i 50 ug/ml PHA + Cpd 1115 ug/m PHA + Cpd If 5 ug/ml PHA + MP 50 ug/ml PHA + MP 15 ug/ml PHA + MP 5 ug/ml Figure 1B