Amplification of regulatory T cells by means of anti-thymocyte immunoglobulins with cytokine, inhibitor of TOR protein kinase and/or differentiating agent

The invention relates to an ex vivo method of preparing regulatory T cells from CD4+ T cells and anti-thymocyte immunoglobulins with cytokine, inhibitor of TOR protein kinase and/or differentiating agent, as well as the regulatory T cells that can be obtained by this method, a pharmaceutical composi...

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Bibliographische Detailangaben
Hauptverfasser:	BERNAUD, JANINE, RIGAL, DOMINIQUE, MATHIASAPON, VIRGINIE, BLOY, CHRISTIAN
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to an ex vivo method of preparing regulatory T cells from CD4+ T cells and anti-thymocyte immunoglobulins with cytokine, inhibitor of TOR protein kinase and/or differentiating agent, as well as the regulatory T cells that can be obtained by this method, a pharmaceutical composition containing them, and uses thereof for treating and/or preventing graft-versus-host disease, post-transplantation tissue or organ rejection, an autoimmune disease, an allergy, or diabetes. The invention also relates to a kit for amplifying regulatory T cells.