Spirocyclic heterocyclic derivatives and methods of their use

Spirocyclic heterocyclic derivatives and methods of their use

Abstract Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the 6 opioid receptor and may be useful, inter alia, for trea...

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Bibliographische Detailangaben
Hauptverfasser: GU, MINGHUA, LEISTER, LARA K, CHU, GUO-HUA, DOLLE, ROLAND E, ZHOU, JEAN Q, AJELLO, CHRISTOPHER W, LE BOURDONNEC, BERTRAND, TUTHILL, PAUL ANSON
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Abstract Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the 6 opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other 6 opioid receptor-mediated conditions.