Binding polypeptides and uses thereof

The invention provides antibodies or antigen binding fragments thereof to DR5 and HER-2. The antibodies and/ or antigen binding fragments thereof comprise variant CDRs comprising highly restricted amino acid sequence diversity. The invention also provides 5 these polypeptides as fusion polypeptides...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SIDHU, SACHDEV S, FELLOUSE, FREDERIC A, BIRTALAN, SARA C
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY COMBINATORIAL CHEMISTRY LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES METALLURGY ORGANIC CHEMISTRY PEPTIDES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The invention provides antibodies or antigen binding fragments thereof to DR5 and HER-2. The antibodies and/ or antigen binding fragments thereof comprise variant CDRs comprising highly restricted amino acid sequence diversity. The invention also provides 5 these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. In addition, compositions and methods of use for treatment of cancer and immune related conditions are provided. 350000_1 (GHMatters) P77907.AU.1