Salts of potassium ATP channel openers and uses thereof

Provided are immediate or prolonged administration of certain salts of KATp channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, 5 pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KA-rP...

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Bibliographische Detailangaben
Hauptverfasser: KASHKIN, KENNETH B, COWEN, NEIL M, YAMOUT, KHALED A
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Provided are immediate or prolonged administration of certain salts of KATp channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, 5 pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KA-rP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs 10 to treat diseases of humans and animals.