Anti-NGF compositions and use thereof

The present invention is directed to antibodies and fragments thereof having binding specificity for NGF, especially those that inhibit the interaction of NGF with TrkA and/or p75 or p75 and/or TrkA. Another embodiment of this invention relates to the antibodies described herein, and binding fragmen...

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Bibliographische Detailangaben
Hauptverfasser:	Stewart, Erica A, Dutzar, Benjamin H, Smith, Jeffrey T.L, Latham, John A, Chang, Betty Yu-Ching, Fan, Pei, Mitchell, Danielle M, Akatsuka, Corinne C, Kovacevich, Brian R, McNeill, Patricia Dianne, Garcia-Martinez, Leon F, Ojala, Ethan W, Billgren, Jens
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is directed to antibodies and fragments thereof having binding specificity for NGF, especially those that inhibit the interaction of NGF with TrkA and/or p75 or p75 and/or TrkA. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.