Treatment of JAK2-mediated conditions

Treatment of JAK2-mediated conditions

Described herein is a method for treating a subject experiencing anemia, comprising administering to the subject an amount of N-(cyanomethyl)-4-[2-[[4-(4- morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide [CYT387] or a related compound effective to maintain or elevate the hemoglobin level. The anem...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FIDA, ROSE, KOWALSKI, MARK MARION, SMITH, GREGG DAVID
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Described herein is a method for treating a subject experiencing anemia, comprising administering to the subject an amount of N-(cyanomethyl)-4-[2-[[4-(4- morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide [CYT387] or a related compound effective to maintain or elevate the hemoglobin level. The anemic subjects including those afflicted with a myeloproliferative disorder, such as primary myelofibrosis.